Career Opportunities

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Join our team to become a CTIzen.  Together, we accomplish the mission to bring cure to patients.

To apply for a currently open position, or for career opportunity inquiry, please send an email to: career@crossignaltherapeutics.com , with your CV and indicate the position you are interested in.

 Immunologist/Oncologist (Job Code: CTi Job 21.02)

We have multiple immediate open positions for scientists with immunology and/or cancer immunology background and  training.  Title (from entry level research scientist to Principal Investigator) and compensation commensurate with experience and qualification.  Scientists with additional industry experience are strongly encouraged to apply.

Responsibilities/Job description

The candidate will function as an integral member to lead and conduct in vitro and in vivo mechanism of drug action/pharmacology studies to support compound selection,  IND enabling , and IND filing.    Primary responsibilities include but are not limited to:

• Design, execute and/or supervise CRO for mechanism of action investigation of small molecule drug candidates in  in vitro  immunological characterization and function assays using primary immune cells, and in vivo using immune-oncology animal models
• Phenotypic/immunological analysis of gene knock-out/knock-in mice for target validation and MOA
• Establish ex vivo culture and  assay platform of primary cancer cells and normal immune cells for in  vitro pharmacodynamic studies
• Perform in vitro and ex vivo  molecule and cellular expression and function analysis of the drug target  genes in tissue culture, animal model system, and in human primary immune      cells and human malignant tissue/cells
• Collaborate with others in  Molecular biology and Screening, and in DMPK and CROs in a multidiscipline environment to meet overall corporate R&D objectives

Education/Experience Requirements:

• PhD in Immunology, or related  life science disciplines with 3+years post-doctoral work experience, preferably in an industrial setting
• A strong background and deep  understanding of T cell biology, antigen presentation, and tumor immune  escape mechanisms and a knowledge of signal transduction in tumorigenesis,  cell growth and apoptosis a must
• Expertise in working with immune systems, such as using FACS analysis, in vitro manipulation of  Primary T cells, and working with animal models, as demonstrated by      peer-reviewed publications. Work experience with immune-oncology animal models a plus
• Knowledge and work experience of gene expression analysis and protein modification in signal transduction pathways, using techniques such as qPCR, immunoblotting and  immunohistochemistry
• Exhibit quick learning ability to new techniques and adjust to new technical challenges, and be analytical and innovative
• Excellent organization skills and  attention to details and ability to multi-task and manage multiple  projects, and with scientific leadership and project management potentials
• Good oral and written communication skills
• Ability to effectively and  clearly explain results to other team members

Job Type

• Full-time

Salary

•      Commensurate with experience and qualification

Benefits

•    Retirement plan, Medical/Dental/Vision insurance plan, stock options

To apply, send an email to: career@crossignaltherapeutics.com  and include 1) a cover letter addressing how you meet the qualifications, (2) curriculum vitae, and (3) three references.

Research Associate  (Job Code: CTi_Job 21.01)

We are currently hiring a Research Associate with experience in molecular biology, cell culture, and bioassays to join our in vitro pharmacology team. 

Responsibilities/Job description

The candidate will function as an integral member to support compound SAR activities.

• Mammalian cell culture maintenance, cell transient and stable transfection with non-viral vector, establishment of stable cell lines
• Perform research using standard molecular biology techniques including techniques for protein lysate preparation and nucleic acid purification, Western-blotting, PCR and qPCR, Immunocytochemistry, immunohistochemistry, ELISA, Fluorescence microscopy, and standard statistical analysis
• Perform flow cytometry analysis and other immunology-based assays
• Support High-throughput compound screening

Education/Experience Requirements:

• BA, BS, or MS in biological science, biotechnology, or related field. 
• 2+ years’ experience in academic, biotech or pharma bench research environment.
• Basic understanding of molecular and cellular biology and immunology assay principles and exhibit quick learning ability to new techniques.
• Ability to follow an established experimental protocol and deliver reliable data is a must. 
• Excellent organization skills and attention to details, and good experimental record-keeping. Familiarity with scientific databases and electronic lab notebooks is a plus.  
• Proficiency with Microsoft Excel and PowerPoint, and Prism Graphpad software for data analysis and graphing, and presentation
• Strong oral and written communication skills.
• Ability to effectively and clearly explain results to other team members.
• Applicants with the following  technical experience and training are encouraged to apply:
  • Experience of flow cytometry analysis and other immunology-based assays
  • Familiar with immunology activities of primary lymphocytes
  • Flow cytometry analysis of effector and target cell populations

Job Type

• Full-time

Salary

•      Commensurate with experience and qualification

Benefits

•    Retirement plan, Medical/Dental/Vision insurance plan, stock options

To apply, please send an email to: career@crossignaltherapeutics.com and reference CTi_Job 21.01, and must include 1) a cover letter addressing how you meet the qualifications, (2) curriculum vitae, and (3) three references. Please do include the cover letter when submitting the application. Documents/materials must be submitted as PDF files.